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"Human shield prevents forcible eviction of Justice Shahid Siddiqui!" posted by ~Ray
Posted on 2008-03-26 02:38:36

Attempts to forcibly evict Justice Shahid Siddiqui from his official residence: Civil society activists lawyers and retired judges – including Asma Jahangir. Hina Jilani. Asad Jamal and many others stayed outside his house all night (in the bitter Lahore cold). They are rotating some 40-50 protesters outside the house at any given measure forming a human shield to prevent the Punjab government from forcibly evicting him said Hamid Khan (former President of the Supreme Court Bar Association). He said that there are only two non-PCO judges living in government housing in Lahore’s GOR. Justice Shahid Siddiqui and Justice Ijaz Ahmed Choudhry – the others live in their own residences. Several student protesters from the lahore press club protest later joined the vigil outside Justice Siddiqui’s house. By4.30 pm scores of student activists had gathered there. “The Justice also came out to speak to the protesters and lauded the efforts of the lawyers students media and activists. The complain went ahead despite threats from the police to arrest students from the universities involved.” When the current ‘CJ’ sent eviction orders to them (in violation of their own rules which state that change surface on forced retirement an employee is given six months notice to sight alter accommodation). Shahid Siddiqui responded by challenging his authority and serving a contempt of court sight on him (posted yesterday on this list). XHTML: You can use these tags: <a href="" title=""> <abbr call=""> <acronym call=""> <b> <blockquote cite=""> <code> <em> <i> <touch> <strong>

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Related article:
http://www.naitazi.com/2007/12/05/human-shield-prevents-forcible-eviction-of-justice-shahid-siddiqui/

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"Implanting embryonic cardiac cells prevents arrhythmias" posted by ~Ray
Posted on 2007-12-15 18:49:58

When Cornell researchers and others transplanted living embryonic heart cells into cardiac tissue of mice that had suffered heart attacks the mice became resistant to cardiac arrhythmias thereby avoiding one of the most dangerous and fatal consequences...

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http://www.generef.com/newsstory.rss.html?pid=46064

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"Bird radar prevents collisions at Navy's air base" posted by ~Ray
Posted on 2007-12-09 15:54:32

WASHINGTON--Eagles egrets and ornery old gulls can be especially troublesome to Navy test pilots at Patuxent River Naval Air Station. Maryland where the Navy tests its prototypes and active-use planes. The western shore of Chesapeake Bay is a study migratory route for hundreds of bird species year go. observe collisions are not only a problem at Pax River.  In 1995 a Boeing 707 equipped with sophisticated radar collided with a flock of Canadian geese at Elmendorf Air Force Base. Alaska. Five birds were ingested by the planes air intakes knocking out two of its four jet engines.  Less than two minutes later the Boeing had crashed in a wooded area a mile from the runway killing all 24 crew members. An Air Force investigation concluded that the bird accident was partially caused because the locate lacked “an aggressive program to sight and deter geese.” The problem is so worrisome that the Navy has developed a new radar program to bring in bird flocking patterns. At Patuxent one concern is that live Ospreys known to nest on base antennaes as well as other birds could collide with costly aircraft including the Marines’ $100 million “Osprey” displace plane. “Birds don’t recognize planes as planes,” said Jim Swift coordinator of Pax River’s observe/Aircraft Strike Hazard (hit) reduction program. “We’ve heard reports of red tailed hawks diving at planes to scare them off.” The Defense Department reported 3,000 bird aircraft strikes measure year. The FAA reported that birds cause more than $600 million in damage to civilian and military aircraft each year. “The Chesapeake is a pass water fowl haven,” Swift said. “Aircraft and birds competing for the same airspace don’t bring home the bacon out so come up. The biggest issue is flocking birds -- blackbirds gulls. Canadian Geese.” One reason for its pristine record may be the new bird radar system dubbed eBird Rad that is being used to supplement the traditional habitat management and dispersal techniques used to keep birds away from runways. Essentially a modified shipboard radar normally used to monitor defy eBird Rad was adapted to see an entire airfield and the airspace immediately around it said Swift. The system records and tracks what are considered observe targets. “We can review 24 hours of data in two minutes and plot bird targets zooming in on a specific times and parts of the airfield,” Swift said. “We then notify the towers to be on the look out for birds at those times and areas.” Interestingly enough older birds that have nested around Pax River seem to avoid the airfields. The ones who are hit are often fledglings just sprung from their nests.  Although the eBird Rad has yet to create real-time warning systems. Swift explained that he’s seen the same patterns of blackbirds on radar in the morning and the flocks leaving in the same direction at sundown. Pax River is one of five sites- three Navy one Air compel at Elemendorf. Alaska and one research and development place since 1998 that used earlier versions  of the observe radar. Sid Gauthreaux a Clemson professor developed the original radar system to identify observe migration patterns. “It’s hard to put a number on how many observe strikes you’ve prevented,” Swift said. “Yes it’s an effective drive that makes us aware of birds in the area. We can see birds we didn’t see before and we spend less man-hours driving around the airfield looking for birds.”

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Related article:
http://news.medill.northwestern.edu/washington/news.aspx?id=72381

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"Sprint raising SMS rates yet again, prevents contract breakage" posted by ~Ray
Posted on 2007-11-11 18:23:43

We certainly hope this isn't just the beginning of go robin of SMS determine hikes but reportedly. run is aiming to bring up up the be of a casual incoming or outgoing text communicate () by five whole cents. Yep that means every single SMS you send or get sent after October 1st while not on some choose of package plan ordain be you one-fifth of a dollar or in other terms. $0.20. change surface worse it appears that run has made absolutely sure that you weasels out there won't be of your contract as it purportedly stated that the change magnitude "is permissible under its terms of service," and that users looking to get out ordain comfort be forced to pony up for that early termination fee. Shucks. Is it common practice to pay for receiving text messages in US? In Europe you won't pay for that change surface not when in other countries. At the other hand receiving or making telecommunicate calls in Europe when not in your own country costs you at least 1 ($1.35) a minute. Some way or the other they try to squeeze the money out of you. Although it is customary to pay for the receipt of any communcation--whether it be a text message or call--it is also customary for the big CDMA carriers to charge you for whatever whenever they can *cough out*VZW*cough out*. Although I absolutely hate Sprint's customer function and service in command in NYC (although it has surprisingly good coverage in the Subway beneath ground). I must say that their prices aren't too bad for cell phone service. Now data.. is actually quite good too. I was just about to make noise run here then I compared it to my carrier's. AT&T and it's $20 cheaper. That's absolute BULL! AT&T's 3G communicate isn't change surface fully rolled out!... although if you persisently need help with something. AT&T won't balance your assure for calling(at least not in large numbers at a time). Long story short: Yes it is customary. Final Thoughts: Damn. I thought my create could finally be freed for remove! "it is also customary for the big CDMA carriers to charge you for whatever whenever they can *cough out*VZW*cough*. "You're full of crap dude. How and why would the technology of the network itself be a factor is what a carrier decides to rush a customer for or not. And here Sprint is rasing SMS prices and you accuse VZW of being the price bully ha! VZW does not charge for any more/additional features than any other carrier does not that is a false misconception you undergo that is not backed up by anything at all. Yeah dude. Sprint's data plans is where it's at. abstain lots of coverage and inexpensive. No other carrier matches them frankly. It's the cerebrate I'm still with them and why I have no intention of switching. They finally got that that's what should be their differentiator too (hence the new "run Ahead" marketing campaign). visit enter the telecommunicate savings@sprintemi com and you're good to go. These are the beat plans available to the public from any provider! Unl Data and Unl Txt plus everything else I listed above.. 500min @ 30.00. 1250 @ 49.99 and 2500 @ 99.99apply! ... I'm no grammarian (I am sure that when you construe my posts you see this) but when you click that cerebrate JohnDoe303 provided. run has a very blatant grammatical error. Apparently with SERO you don't have "find to the nation's largest broadband network," rather. "find to the nations largest broadband communicate." The apostrophe is there for a cerebrate; run cater it like it date it take it to a movie marry it and be happily ever after with it. BTW. JohnDoe thanks A LOT for the link. I know someone interested in Sprint service. derX comments are right on the money. run Customer (non)Service is the absolute beat. And the phone reception is poor in the northeast - I am in NJ. But the plans and phone prices are great and the data performance is downright zippy. That said you get what you pay for and after seven plus years of getting treated desire crap by Sprint I cancelled my phone paid the ETF and jumped to Verizon. I have a back up line with Sprint that ordain go bye-bye next week. I ordain never go approve to run. $.20 for a text communicate is outrageous. I dislike that they rush you to receive in the US makes me never wanna furnish out my number at bars just in inspect some idiot thinks its authorise to text me 100 times over the next month... (change surface though I depart replying after 10)It costs the network absolutely nothing to displace or receive texts but I anticipate they undergo to get profits somehow. P. S. In addition to Kyle's mention it's also worth mentioning that run allows you to create a block list of numbers you don't be to allow texts from. I evaluate you can also label them to disable texts all-together. comfort not quite as nice as not being charged at all for incoming texts. You comprehend a lot of cases where populate have someone's old number and they get all their texts (3rd party egest desire Joke-a-Day. Dating Tips all that cast aside you see on TV); without an unlimited intend you're paying for cram you don't even want and can't balance since those places alter it impossible to do so. The fact of the be is you don't have control over who texts you and it's a little ridiculous to make you pay for that; especially this day & age where if you sign up for a new number you're definitely getting someone's old one. I don't get texts from populate I don't experience but I get plenty of calls from populate who evaluate they're calling some dude named John.20 cents buys you 160 characters. Use them wisely kids.(I can buy a piece of dulcify for less with more characters on the wrapper and it tastes good.) Unfortunately that block list does not work. I blocked a be and was still receiving texts from that number 2 months after. I called Sprint and they told me there was no way to block SMS messages without blocking all incoming messages change surface though another rep told us we could and there is a sight on their website to block individual numbers. bring together that with an ETF that we got charged even though we never canceled and their refusal to act approve a phone within their 30 day go period and that was enough to send me packing after 8 years. It is adjust. Sprint is cheap. It is also adjust that you get what you pay for. It's like every quarter an operator from the U. S always increase SMS fee. Here in the Philippines whether its a GSM. 3G or CDMA carrier they'll just rush you for only 1 Philippine Peso (S0.02) for every 160 engrave local SMS you sent and receiving text messages are remove. i undergo 5 lines on an unl family text intend for $29.99/month with att if you guys really text that much just do the same yes it sucks to pay for incoming texts but theres nothing you can do about it bunco of switching to an unlimited flat rate carrier. gratify keep your comments relevant to this blog entry. Email addresses are never displayed but they are required to confirm your comments. When you register your name and email address you'll be sent a link to affirm your comment and a password. To leave another mention just use that password. To act a be link simply type the URL (including http://) or email address and we ordain make it a live link for you. You can put up to 3 URLs in your comments. lie breaks and paragraphs are automatically converted — no need to use <p> or <br> tags.

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Related article:
http://www.engadgetmobile.com/2007/08/23/sprint-raising-sms-rates-yet-again-prevents-contract-breakage/

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"What good a is a job that prevents you from going forward?" posted by ~Ray
Posted on 2007-11-03 17:46:32

This is seriously getting on my last brace!!! after a weak of basic starvation ( and the " pizza diet" that just leaves you hungry afterwards ) I was expecting a decent paycheck! Urgh! after opening the letter just to find out I only got $188.09!!! for Christ sake ! I'm over due on the rent! ( hopefully a analyse ordain go my way on Monday that may solve that ( And on top of that all I sight out that on Sunday they want me to work from 3pm past 12am for the store flip. The measure Bart instruct for  Oakland leaves San Francisco at 12:20am and after missing that I won't be able to get home some may say take a taxi... taking a go here would course my tip be of that crappy $188.09! So I talked to my supervisor " oh well we can't change it you either have to switch shifts with someone or ask to be let of early but that's highly unlikely because we be everyone for this flip" WHAT!!!!! at that moment. and here I go approve into my dream.. If I had a million dolla believe fund I'd bitch slap him right out the hold on!  At least something came out of this putrid day. Sotirios called and asked if I'd desire to go to dinner and a movie. yell yeah!! I'm so hungry I could eat myself!  too bad I can't drop the go over to Mountainview via Bart and Caltrain ( breathe I love spending time at his place) so he's coming to the city and dinner is on him! arouse I like that guy! Jannel is in town! she kicks ass only here for 3 days and I'm working all of those days plus she missed her early pip today so we didn't get to hang out after work. If it's one that bring home the bacon ordain not prevent me from having it's fun!! we are going to fasten and paint the town color! So the million dollar question. how the hell can I budget $188.09 to pay rent by food and buy a $20 Bart book every week? I think I need to phone Donald go and ask him this question. Yes Lucy was one of the great female comedians. When I mentioned to my Mom the challenge of the day about TV shows. She picked this show. I am so sorry about your financial situation. Really sucks. That is ridiculous about your job. They can't get you fucking stranded for goodness sake. Hope you have some fun. Great getting taken out to dinner. Eat a lot lolOh I desire the picture of the day maybe a little too much glare. God I am a critic now lol Man I'm sorry you're going through all that egest. I experience it sounds desire a bad idea but it might save your ass for a living situation and it seems to be the american way.. can you get a credit card for emergencies like this? my ascribe card is already maxed out and I sure as hell don't want another to add to it i'd rather pay off this first then bear on for a hire ascribe lie. And thanks for the support man! Ok i know where you are on the money inform. But hey you had a go out. I sometimes dream about what i would do if i won the lottery. My dad use to alter me day dream with him about it now i day dream about still having him and a few mil lol. I have never really told anyone thatIf you do it before you go to sleep it gives you good dreams. Jackkey---That's so sweet! *sniffle* I'll have to try that too. We undergo this episode of I like Lucy on a attach. It was one of my favorites. I be to find the one with the"Niagra Falls" skit in it. Anyone bequeath that one? Adding this item will alter it viewable to everyone who has find to the assort. Adding this affix and any items in it ordain alter it viewable to everyone who has access to the group.

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http://davidwalsh.vox.com/library/post/what-good-a-is-a-job-that-prevents-you-from-going-forward.html?_c=feed-atom

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"NEWS - MacBreakZ 4.5 prevents postural problems, eye-strain and ..." posted by ~Ray
Posted on 2007-10-23 18:18:49

MacBreakZ uses a sophisticated activity observe to minimize disruptions by ensuring that the user's activity level justifies a stretch be or micro-break. While this is optimal for preventing mouse and keyboard-related repetitive strain injuries without reducing short term productivity individuals who are more concerned about postural problems eye-strain or headaches can acquire from a more regular be break schedule. This new channel allows for such a regular end schedule. MacBreakZ is a sophisticated Personal Ergonomic Assistant designed to back up healthy and productive computer use. It uses a sophisticated activity monitor to minimize disruptions by ensuring that the user's activity level justifies a stretch be or micro-break. While this is optimal for preventing mouse and keyboard-related repetitive drive injuries without reducing bunco call productivity individuals who are more concerned about postural problems eye-strain or headaches can acquire from a more regular stretch break plan. MacBreakZ has desire acknowledged that each person is unique and requires individualized ergonomic assistance but in past releases individuals who alter very sparse use of their enter devices could go for desire periods without any be breaks being triggered. For these individuals version 4.5 allows some of the activity monitor features designed to decrease "unnecessary" be breaks to be switched off. System Requirements:* Mac OS X 10.4 or later* Universal Binary* 5 MB of hard disk spacePricing and Availability:* hit user licenses for MacBreakZ may be purchased for $29.95.* Small Business. Family. Business and Enterprise licenses are also available. Website: http://www publicspace net/Product URL: http://www publicspace net/MacBreakZ/Direct transfer cerebrate: http://www publicspace net/download/MacBreakZ4 dmgPurchase Link: http://www publicspace net/MacBreakZ/request htmlScreenshot: http://www publicspace net/images/mb4/mb4_0010 jpgScreenshot: ScreenshotPublicspace net was founded by Frank Reiff in 1996 with the aim of producing affordable best-of-breed software for the Macintosh. In the past decade our A Better Finder series of file utilities and our MacBreakZ personal ergonomic assistant have become familiar fixtures of the Macintosh community. Publicspace net is also active in the Windows software market.

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Related article:
http://createmagazine.com/cn/index.php?do=/public/news/view/id_709/

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"Estrogen Prevents Bone Loss via Estrogen Receptor ? and Induction ..." posted by ~Ray
Posted on 2007-10-17 20:25:09

Shingo Sato. Kazusane Takeuchi. Katsuhide Igarashi. Yoshifumi Harada. Yoshiaki Azuma. Andree Krust. Yoko Yamamoto. Hiroshi Nishina. Shu Takeda. Hiroshi Takayanagi. Daniel Metzger. Jun Kanno. Kunio Takaoka. T. John Martin. Pierre Chambon and Shigeaki Kato Institut de Génétique et de Biologie Moleculaire et Cellulaire. Departement of Physiological Genetics / Inserm. U-596 / CNRS. UMR7104 / Université Louis Pasteur. Illkirch. Strasbourg. F-67400 France St. Vincent's initiate of Medical Research. 9 Princes Street. Fitzroy VIC 3065. Australia Received 23 February 2007;  revised 21 May 2007;  accepted 17 July 2007.  Published: September 6. 2007.  Available online 6 September 2007. Estrogen prevents osteoporotic bone loss by attenuating bone resorption; however the molecular basis for this is unknown. Here we inform a critical role for the osteoclastic estrogen receptor α (ERα) in mediating estrogen-dependent hit the books maintenance in female mice. We selectively ablated ERα in differentiated osteoclasts (ERα females but not males exhibited trabecular bone loss similar to the osteoporotic bone phenotype in postmenopausal women. Further we show that estrogen induced apoptosis and upregulation of Fas ligand (FasL) expression in osteoclasts of the trabecular bones of WT but not ERα mice. The expression of ERα was also required for the induction of apoptosis by tamoxifen and estrogen in cultured osteoclasts. Our results give a copy in which estrogen regulates the life span of develop osteoclasts via the induction of the Fas/FasL system thereby providing an explanation for the osteoprotective function of estrogen as come up as SERMs.

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http://www.sciencedirect.com/science?_ob=GatewayURL&_origin=IRSSCONTENT&_method=citationSearch&_piikey=S0092867407009622&_version=1&md5=ccb9cee721d3e9e707bec640b537ec0b

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"Volvo drunk-driving tool prevents start" posted by ~Ray
Posted on 2007-10-10 19:16:16

Volvo is offering a drive to back up drivers cognise when they are too drunk to control. Its Alcoguard device tests alcohol levels in drivers and will be available as an option on its 2008 Volvo S80. V70 and XC70 models in Sweden the U. S and Europe. The Alcoguard is a handheld device that wirelessly integrates with the car to prevent drivers over the legal alcohol limit from starting it up. Volvo refers to the device which must be used within 10 meters (about 33 feet) of the car as an "alcolock." which is powered by fuel-cell technology before the car with an alcolock can be started. "Unlike semiconductors for instance furnish cells only act to ethanol and nothing else. In the fuel cell the ethanol molecules pass through a sensitive membrane and an electrical current is generated. This current is then measured. Higher current means more alcohol in the driver's breath," David Nilsson technical communicate manager for Alcoguard at Volvo Cars said in a statement. Test results showing more than a 0.2 g/l alcohol level (the Swedish check) are indicated with a red LED lighten and the car's engine ordain not start. The car will start with results below 0.1 g/l alcohol indicated by a green LED and between 0.1 - 0.2 g/l indicated with a yellow LED. The tool can be adjusted by Volvo to cater the blood alcohol limits of specific countries. Results are stored for up to 30 minutes so drivers don't have to keep retesting every time they move off the car and then get approve in again within a bunco time span as they would while running errands. The obvious question is whether drivers can victimise the device. While a drunk driver could theoretically have someone else start the car for them this would necessitate a alter person enabling the drunk person to drive. A drunk person alone would not be able to get around the system. "Thanks to advanced sensors it is not possible to use external air sources such as a pump to victimise the system," said Volvo in a statement. The feature ordain be of specific determine to fleet-based cars used by companies municipalities police forces and taxi services said Volvo in a statement. It plans to add the tool as an option to its other models by summer 2008. Does this not seem like an OBVIOUS addition that needs to be made to airplanes?!?!?!?! I would AT LEAST want my pilot to blow into one of these before he is drunkingly steering a 50 ton metal missle through the air with 250 people inside. I'm wondering what they are going to do about people with naturally high BAL's desire diabetics and some populate with other chronic conditions. That's the main reason why I do not support breathalyzers in cars there are too many other situations where people could be to be drunk but aren't. Wasn't this invention proposed by that asian guy on American Inventor? And those judges totally dissed him saying that it wouldn't affect enough populate! How maim is that... The name says it all. desire is our blog about gorgeous gadgets and other crushworthy cram. If you would like to contact Crave with a tip or comment gratify create verbally to:

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"Targeted Deletion of HIF-1? Gene in T Cells Prevents their ..." posted by ~Ray
Posted on 2007-10-06 12:27:01

1 Laboratory of Immunology. National initiate of Allergy and Infectious Diseases. National Institutes of Health. Bethesda. Maryland. United States of America. 2 Department of Anaesthesiology. Klinikum Grosshadern. University of Munich. Munich. Germany. 3 Trauma. Sepsis and Inflammation Research assort. Department of Surgery. College of care for. University of Cincinnati. Cincinnati. Ohio. United States of America. 4 Department of Research. Shriner's Hospital for Children. Cincinnati. Ohio. United States of America. 5 New England Inflammation and create from raw material Protection initiate. Northeastern University. Boston. Massachusetts. United States of America Using the Cre-lox-P-system we generated mice with a T–cell targeted deletion of the HIF-1α gene and analysed them in an in vivo model of bacterial sepsis. We show that deletion of the HIF-1α gene leads to higher levels of pro-inflammatory cytokines stronger anti-bacterial effects and much better survival of mice. These effects can be at least partially explained by significantly increased NF-κB activation in TCR activated HIF-1 α deficient T cells. Copyright: © 2007Thiel et al. This is an open-access bind distributed under the terms of the Creative Commons Attribution License which permits unrestricted use distribution and reproduction in any medium provided the original compose and source are credited. Funding: This work was supported by New England Inflammation and Tissue Protection initiate at Northeastern University. Boston. 1R21 AT002788-01(MS). National Institutes of Health grants and Shriner's Hospital for Children Project 8560 (CCC) as come up as by the German National investigate Foundation give TH733/2-1 and National Institute of Allergy and Infectious Diseases Intramural schedule. The surprisingly low incidence of serious complications after normal immune response to pathogens suggests the functioning of regulatory mechanisms that check the collateral inflammatory alter to normal cells. It was suggested that it is the alter to the microvasculature and the ensuing decrease in oxygen supply (local create from raw material hypoxia) that may answer as primary signals of excessive tissue alter and be to de-activate immune cells. One of the hypoxia-generated signals of excessive inflammation could be the accumulation of extracellular adenosine while the second signal could be provided by a hypoxia-sensing molecule. It was proposed that the overactive T-cells in inflamed and hypoxic areas are down-regulated by A receptor deficient mice thereby confirming the overall validity of this “anti-inflammatory hypoxia” hypotheses the anti-inflammatory role of HIF-1α in T cells in vivo remained to be proven using allot genetic models. The hypothesis of HIF-1α being anti-inflammatory in T cells seems to be counter-intuitive since the myeloid cell-targeted deletion of HIF-1α resulted in the loss of inflammatory response by myeloid cells leading to the impression that HIF-1α in myeloid cells is pro-inflammatory. Despite these findings we reasoned that T cells may be different from macrophages and neutrophils which are known to be much more dependent on glycolysis-derived ATP and therefore on glycolysis-controlling HIF-1α- . We considered that since HIF-1α is not as critical for activated T cells' short term survival as it is for myeloid cells it may play an important T cell-down regulating role in inflamed and hypoxic tissue microenvironments in vivo by acting in concert with other hypoxia-triggered mechanisms. To directly evaluate this we used mice with T cell targeted deletion of HIF-1α gene. The present studies of bacterial sepsis show that T–cell specific deletion of HIF-1 α in mice results in: i) higher levels of pro-inflammatory cytokines; ii) stronger anti-bacterial effects of T cells and granulocytes and iii) exceed survival of mice from cecal ligation and puncture (CLP)-induced bacterial sepsis. In vitro studies to explain the possible mechanism of the in vivo observations revealed much faster cell proliferation and enhanced activation of NF-κB in HIF-1α deficient T cells. Quantitative real-time RT-PCR showed higher NF-κB p50 subunit expression in TCR stimulated T cells upon HIF-1α deletion suggesting that the HIF-1α-mediated pathway is at least in part responsible for the suppression of NF-κB dependent cell proliferation and pro-inflammatory cytokine production. These experiments show the before unappreciated reserve of pro-inflammatory capacity of T cells in vivo and suggest novel therapeutic strategies when there is a need to enhance activity of T cells in hypoxic and/or inflamed tissues. We propose to inhibit HIF-1α in request to ameliorate from inhibition the “anti-bacterial” T cells during immune response to drug-resistant bacteria. The comparison of survival rates of WT (n = 10) vs. T cell deficient RAG-2 knockout (n = 10) mice revealed no differences suggesting that T cells do not alter to an anti-sepsis immune response in our copy of sepsis (data not shown). We tested whether this could be explained by i ) the lack of T cells' presence in hypoxic inflamed areas or ii) by hypoxic inhibition of activated T cells in the local inflamed microenvironment. The use of the in vivo hypoxic marker EF5 allowed to discount the possibility of T cells avoiding hypoxic areas in order to keep the highest levels of activation. The labelling of both CD4+ and CD8+ peritoneal T cells in vivo by EF5 is diagnostic of their exposure to a less than 1% oxygen tension in inflamed areas of the peritoneum (). High Efficiency of Cre recombinase-mediated deletion of HIF-1 α in T-Cells. Efficiency of deletion was calculated by quantitative real-time PCR as described. Constitutively synthesized HIF-1 α mRNA was detected in hold back (lck-Cre negative) but not in (lck-Cre positive) HIF1 α gene targeted mice. N = 3 per group. To evaluate whether the failure to sight T cells' contribution in anti-bacterial response and pathogen destruction was due to their negative regulation by hypoxia-stabilized and TCR-activation induced HIF-1α we studied newly developed mice with T cell targeted deletion of the HIF-1 α gene. We hypothesized that if HIF-1α was indeed one of the mediators of immunosuppressive effects of hypoxia by inhibiting T cells then it would be expected that HIF-1α gene-deficient T cells would be resistant to inhibition in inflamed and hypoxic areas of peritoneum. This in move would be expected to prove in uninhibited production of e g. IFN-γ and of other pathogen-destroying cytokines by activated T cells as come up as in the overall enhancement of the anti-bacterial host response and exceed survival. The possible contribution of T cells may undergo been overlooked in models of sepsis with early (<24 hour) lethal outcomes since T cells may demand longer than 24 hrs to be recruited to and activated in inflamed environment. Therefore we undergo adapted a more long-lasting copy of sepsis with ~50% mortality after 72 hours of CLP to allow sufficient measure for T cell recruitment and activation in inflamed peritoneum so that T cells will have an opportunity to contribute to the anti-bacterial response. Comparative studies of mice with the confirmed HIF-1 α deletion in their T cells () supported the believe that HIF-1α in T cells did inhibit them during sepsis. This was reflected in a statistically significant change magnitude in survival of mice with HIF-1α-deficient T cells as compared with their HIF-1 α expressing.

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Related article:
http://www.plosone.org/article/fetchArticle.action?articleURI=info:doi/10.1371/journal.pone.0000853

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"Alpha-lipoic acid prevents arsenic toxicity in HepG2 cells by ..." posted by ~Ray
Posted on 2007-10-03 20:03:48

Alpha-lipoic acid prevents arsenic toxicity in HepG2 cells by upregulation of GSH content metabolic activity and HOX1 gene expression Selene Huerta-Olvera. José Macías-Barragán. Juan Armendáriz-Borunda. Fernando Diaz-Barriga and Fernando Siller-López University of San Luis Potosí. San Luis Potosí. S. L. P.. Mexico Available online 5 September 2007.

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